{"id":24,"date":"2012-09-13T17:32:17","date_gmt":"2012-09-13T15:32:17","guid":{"rendered":"http:\/\/auditore.cab.inta-csic.es\/manrubia\/?page_id=24"},"modified":"2025-09-11T13:54:10","modified_gmt":"2025-09-11T11:54:10","slug":"publications","status":"publish","type":"page","link":"https:\/\/auditore.cab.inta-csic.es\/manrubia\/publications\/","title":{"rendered":""},"content":{"rendered":"

2025<\/strong><\/h3>\n

150. Hierarchical genotype networks and incipient ecological speciation in Q\u03b2 phage quasispecies
\nSeoane, L.F., Secaira-Morocho, H., L\u00e1zaro, E., Manrubia, S.
\narXiv preprint arXiv:2411.07110<\/a><\/p>\n

149. Assay: Paradoxes dels viatges en el temps (Paradoxes of time travel)
\nManrubia, S.
\nto appear<\/em><\/p>\n

2024<\/strong><\/h3>\n

148. Optimal COVID-19 vaccine prioritization by age depends critically on inter-group contacts and vaccination rates<\/a>
\nAtienza-Diez, I., Rodriguez-Maroto, G., Ares, S., Manrubia, S.
\nRoyal Society Open Science<\/em> 11<\/strong> (12), 240753<\/p>\n

2023<\/strong><\/h3>\n

147. Physics of diffusion in viral genome evolution<\/span><\/a>
\nManrubia, S., Cuesta, J.
\nProceedings of the National Academy of Sciences USA<\/em> 120<\/strong>, e2310999120<\/span><\/p>\n

146. Entropic contribution to phenotype fitness<\/a>
\nCatal\u00e1n, P., Garc\u00eda-Mart\u00edn, J. A., Aguirre, J., Cuesta, J., Manrubia, S.
\nJournal of Physics A: Math. Theor. <\/em>56<\/b><\/strong>, 345601
\n<\/span><\/span><\/span>https:\/\/arxiv.org\/abs\/2304.05311 <\/a><\/p>\n

145. Vaccination strategies in structured populations under partial immunity and reinfection<\/a>
\nRodriguez-Maroto<\/span><\/span>, G., Atienza-Diez<\/span><\/span>, I.,\u00a0Ares<\/span><\/span>, S.,\u00a0Manrubia, S.
\n<\/span><\/span><\/span>Journal of Physics A: Math. Theor. <\/em>56<\/b><\/strong>, 204003 <\/span><\/span><\/span><\/p>\n

2022<\/strong><\/h3>\n

144. Genotype-to-protein map and collective adaptation in a viral population<\/a>
\nVillanueva, A., Secaira-Morocho, H., Seoane, L.F., L\u00e1zaro, S., Manrubia, S.
\nBiophysica<\/em> 2<\/strong>, 381<\/p>\n

143. Standing genetic diversity and transmission bottleneck size drive adaptation in bacteriophage Q\u03b2<\/a>
\nSomovilla, P., Rodr\u00edguez-Moreno, A., Arribas, M., Manrubia, S., L\u00e1zaro, E.
\nInternational Journal of Molecular Sciences <\/em>23<\/strong>, 8876<\/p>\n

142. The long and winding road to understanding organismal construction: Reply to Comments on “From genotype to organisms: State-of-the-art and perspectives of a cornerstone in evolutionary dynamics”<\/a>
\nManrubia, S., Cuesta, J. A., Aguirre, J., Ahnert, S. E., Altenberg, L., Cano, A. V., Catal\u00e1n, P., Diaz-Uriarte, R., Elena, S. F., Garc\u00eda-Mart\u00edn, J. A., Hogeweg, P., Khatri, B. S., Krug, J., Louis, A. A., Martin, N. S., Payne, J. L., Tarnowski, M. J., Wei\u00df, M.
\nPhysics of Life Reviews <\/em>42, <\/strong>19<\/span><\/p>\n

141. Defective subviral particles modify ecological equilibria and enhance viral coexistence<\/a>
\nLuc\u00eda-Sanz, A., Aguirre, J., Fraile, A., Garc\u00eda-Arenal, F., Manrubia, S.
\nFrontiers in Virology<\/em> 2<\/strong>, 929851<\/span><\/p>\n

140. Report: Collaboration network of the National Centre for Biotechnology (CSIC), 2016-2021
\nManrubia, S., Atienza-Diez, I., Seoane, L.
\ndigital.csic.es\/handle\/10261\/259107<\/a><\/p>\n

139. The simple emergence of complex molecular function<\/a>
\nManrubia, S.
\nPhilosophical Transactions of the Royal Society A <\/em>380<\/strong>, 20200422<\/span>
\narxiv.org\/abs\/2105.11784<\/a><\/p>\n

138. Individual risk-aversion responses tune epidemics to critical transmissibility (R<\/em>=1)<\/a>
\nManrubia, S. and Zanette, D. H.
\nRoyal Society Open Science\u00a0 <\/em>9<\/strong>, 211667<\/p>\n

2021<\/strong><\/h3>\n

137. From genotypes to organisms: State-of-the-art and perspectives of a cornerstone in evolutionary dynamics<\/a>
\nManrubia, S., Cuesta, J. A., Aguirre, J., Ahnert, S. E., Altenberg, L., Cano, A. V., Catal\u00e1n, P., Diaz-Uriarte, R., Elena, S. F., Garc\u00eda-Mart\u00edn, J. A., Hogeweg, P., Khatri, B. S., Krug, J., Louis, A. A., Martin, N. S., Payne, J. L., Tarnowski, M. J., Wei\u00df, M.
\nPhysics of Life Reviews<\/em> 38<\/strong>, 55-106<\/p>\n

136. Unresolved advantages of multipartitism in spatially structured environments<\/a>
\nZwart, M. P., Blanc, S., Johnson, M., Manrubia, S., Michalakis, Y., Sofonea, M.
\nVirus Evolution <\/em>7<\/strong>, <\/em>veab004<\/p>\n

2020<\/strong><\/h3>\n

135. Viewpoint: The uncertain future in how a virus spreads<\/a>
\nManrubia, S.
\nPhysics<\/em> 13<\/strong>, 166<\/p>\n

134. The turning point and end of an expanding epidemic cannot be precisely forecast<\/a>
\nCastro, M., Ares, S., Cuesta, J. A., Manrubia, S.
\nProceedings of the National Academy of Sciences USA<\/em> 117<\/strong>, 26190-26196<\/span><\/p>\n

133. Populations of genetic circuits are unable to find the fittest phenotype as a result of phenotypic bias in a multilevel genotype-phenotype map<\/a>
\nCatal\u00e1n, P., Manrubia, S., Cuesta, J. A.
\nJournal of the Royal Society Interface<\/em> 17<\/strong>, 20190843<\/p>\n

132. Redes de genotipos: los senderos de la evoluci\u00f3n<\/a>
\nManrubia, S., Cuesta J. A.
\nInvestigaci\u00f3n y Ciencia<\/em>, April 2020, p. 38-47<\/p>\n

131. Fat tails and Black Swans: Exact results for multiplicative processes with resets<\/a>
\nZanette, D. H., Manrubia, S.
\nChaos <\/em>30<\/strong>, 033104
\narxiv.org\/abs\/2105.11679<\/a><\/p>\n

130. Epistasis between cultural traits causes paradigm shifts in cultural evolution<\/a>
\nPascual, I., Aguirre, J., Manrubia, S., Cuesta, J. A.
\nRoyal Society Open Science <\/em>7<\/strong>, <\/em>191813<\/p>\n

2019<\/strong><\/h3>\n

129. Evolutionary dynamics in the RNA bacteriophage Qbeta depends on the pattern of change in selective pressures<\/a>
\nSomovilla, P., Manrubia, S., L\u00e1zaro, E.
\nPathogens<\/em> 8<\/strong>, 80<\/p>\n

128. Parsimonious scenario for the emergence of viroid-like replicons de novo<\/a>
\nCatal\u00e1n, P., Elena, S. F., Cuesta, J. A., Manrubia, S.
\nViruses<\/em> 11<\/strong>, 425<\/p>\n

127. Endemicity and prevalence of multipartite viruses under heterogeneous between-host transmission<\/a>
\nValdano, E., Manrubia, S., G\u00f3mez, S., Arenas, A.
\nPLoS Computational Biology<\/em> 15<\/strong>, e1006876<\/p>\n

2018<\/strong><\/h3>\n

126. Limited role of spatial self-structuring in emergent trade-offs during pathogen evolution<\/a>
\nBuend\u00eda, V., Mu\u00f1oz, M. A., Manrubia, S.
\nScientific Reports<\/em> 8<\/strong>, 12476<\/p>\n

125. Theoretical approaches to disclosing the emergence and adaptive advantages of multipartite viruses<\/a>
\nLuc\u00eda-Sanz, A., Aguirre, J., Manrubia, S.
\nCurrent Opinion in Virology<\/em> 33<\/strong>, 89-95<\/p>\n

124. Statistical theory of phenotype abundance distributions: A test through exact enumeration of genotype spaces<\/a>
\nGarc\u00eda-Mart\u00edn, J. A., Catal\u00e1n, P., Manrubia, S., Cuesta, J. A.
\nEurophysics Letters<\/em> 123<\/strong>, 28001
\nEPL Focus Issue Evolutionary modeling and experimental evolution<\/em>, edited by J. A. Cuesta, J. Krug and S. Manrubia<\/p>\n

123. On the networked architecture of genotype spaces and its critical effects on molecular evolution<\/a>
\nAguirre, J., Catal\u00e1n, P., Cuesta, J. A., Manrubia, S.
\nOpen Biology<\/em> 8<\/strong>, 180069<\/p>\n

122. Differences in adaptive dynamics determine the success of virus variants that propagate together<\/a>
\nArribas, M., Aguirre, J., Manrubia, S., L\u00e1zaro, E.
\nVirus Evolution<\/em> 4<\/strong>, vex043<\/p>\n

121. Adding levels of complexity enhances robustness and evolvability in a multilevel genotype-phenotype map<\/a>
\nCatal\u00e1n, P., Wagner, A., Manrubia, S., Cuesta, J. A.
\nJournal of the Royal Society Interface<\/em> 15<\/strong>, 20170516<\/p>\n

2017<\/strong><\/h3>\n

120. Multipartite viruses: adaptive trick or evolutionary treat?<\/a>
\nLuc\u00eda-Sanz, A., Manrubia, S.
\nnpj Systems Biology and Applications<\/em> 3<\/strong>, 34<\/p>\n

119. The space of genotypes is a network of networks: implications for evolutionary and extinction dynamics<\/a>
\nYubero, P., Manrubia, S., Aguirre, J.
\nScientific Reports<\/em> 7<\/strong>, 13813<\/p>\n

118. Disentangling the effects of selection and loss bias on gene dynamics<\/a>
\nIranzo, J., Cuesta, J. A., Manrubia, S., Katsnelson, M., Koonin, E. V.
\nProceedings of the National Academy of Sciences USA<\/em> 114<\/strong>, E5616<\/p>\n

117. Distribution of genotype network sizes in sequence-to-structure genotype-phenotype maps<\/a>
\nManrubia, S. and Cuesta, J. A.
\nJournal of the Royal Society Interface<\/em> 14<\/strong>, 20160976<\/p>\n

116. Internal disequilibria and phenotypic diversification during replication of hepatitis C virus in a non-coevolving cellular environment<\/a>
\nMoreno, E., Gallego, I., Gregori, J., Luc\u00eda-Sanz, A., Soria, M.E., Castro, V., Beach, N. M., Manrubia, S., Quer, J., Esteban, J. I., Rice, Ch. M., G\u00f3mez, J., Gastaminza, P., Domingo, E. and Perales, C.
\nJournal of Virology<\/em> 91<\/strong>, e02505<\/p>\n

115. Enumerating secondary structures and structural moieties for circular RNAs<\/a>
\nCuesta, J. A. and Manrubia, S.
\nJournal of Theoretical Biology<\/em> 419<\/strong>, 375-382<\/p>\n

114. Adaptive multiscapes. An up-to-date metaphor to visualize molecular adaptation<\/a>
\nCatal\u00e1n, P., Arias, C. F., Cuesta, J. A. and Manrubia, S.
\nBiology Direct <\/em> 12<\/strong>, 7<\/p>\n

2016<\/strong><\/h3>\n

113. The vast unknown microbial biosphere<\/a>
\nPedr\u00f3s-Ali\u00f3, C. and Manrubia, S.
\nProceedings of the National Academy of Sciences USA<\/em> 113<\/strong>, 6585<\/p>\n

112. Getting to know viral evolutionary strategies: Towards the next generation of quasispecies models<\/a>
\nManrubia, S. and L\u00e1zaro, E.
\nCurrent Topics in Microbiology and Immunology<\/em> 392<\/strong>, 201-217<\/p>\n

2015<\/strong><\/h3>\n

111. Demography-based adaptive network model reproduces the spatial organization of human linguistic groups<\/a>
\nCapit\u00e1n, J. A. and Manrubia, S.
\nPhysical Review E<\/em> 92<\/strong>, 062811<\/p>\n

110. Modelling viral evolution and adaptation<\/a>
\nManrubia, S.
\nTrends in Mathematics. Research Perspectives CRM Barcelona, vol. 4<\/em>. M. Corbera, J. M. Cors, J. Llibre and A. Korobeinikov, Eds. pp. 125-129. Birkh\u00e4user, Springer.<\/p>\n

109. Tipping points and early warning signals in the genomic composition of populations induced by environmental changes<\/a>
\nAguirre, J. and Manrubia, S.
\nScientific Reports<\/em> 5<\/strong>, 9664<\/p>\n

108. New patterns in human biogeography revealed by networks of contacts between linguistic groups<\/a>
\nCapit\u00e1n, J. A., Axelsen, J. B. and Manrubia, S.
\nProceedings of the Royal Society of London B<\/em> 282<\/strong>, 20142947<\/p>\n

107. Evolution on neutral networks accelerates the ticking rate of the molecular clock<\/a>
\nManrubia, S. and Cuesta, J. A.
\nJournal of the Royal Society Interface<\/em> 12<\/strong>, 20141010<\/p>\n

106. Dynamical community structure of populations evolving on genotype networks<\/a>
\nCapit\u00e1n, J. A., Aguirre, J. and Manrubia, S.
\nChaos, Solitons & Fractals<\/em> 72<\/strong>, 99-106<\/p>\n

2014<\/strong><\/h3>\n

105. toyLIFE: a computational framework to study the multi-level organization of the genotype-phenotype map<\/a>
\nArias, C. F., Catal\u00e1n, P., Manrubia, S. and Cuesta, J. A.Multiplicative processes in social systems
\nScientific Reports<\/em> 4<\/strong>, 7549<\/p>\n

104. Efficient HIV-1 inhibition by a 16 nt-long RNA aptamer designed by combining in vitro selection and in silico optimisation strategies<\/a>
\nS\u00e1nchez-Luque, F., Stich, M., Manrubia, S., Briones, C. and Berzal-Herranz, A.
\nScientific Reports <\/em>4<\/strong>, 6242<\/p>\n

103. Susanna Manrubia and Dami\u00e1n H. Zanette, Genes y genealog\u00edas. Sobre nuestra herencia cultural y gen\u00f3mica<\/a>
\n(Genes and genealogies. On our cultural and genomic inheritance.)<\/em> ISBN 9788437092935, 164 pp.
\nColecci\u00f3n Sin Fronteras<\/em>. C\u00e1tedra de Divulgaci\u00f3n de la Ciencia, Publicaciones de la Universidad de Valencia.<\/p>\n

102. Large-scale genomic analysis suggests a neutral punctuated dynamics of transposable elements in bacterial genomes<\/a>
\nIranzo, J., G\u00f3mez, M. L\u00f3pez de Saro, F. J. and Manrubia, S.
\nPLoS Computational Biology<\/em> 10<\/strong>, e1003680<\/p>\n

101. The ecology of human linguistic groups<\/a>
\nCapit\u00e1n, J. A. and Manrubia, S.
\nIn: Frontiers in Ecology, Evolution and Complexity<\/em><\/a>, pp. 256-265. M. Ben\u00edtez, O. Miramontes and A. Valiente-Banuet eds. CopIt arXives, Mexico.<\/p>\n

100. River density and landscape roughness are universal determinants of linguistic diversity<\/a>
\nAxelsen, J. B. and Manrubia, S.
\nProceedings of the Royal Society of London B<\/em> 281<\/strong>, 20133029
\nThis paper has been featured in Science<\/em> 344<\/strong>, 340 (Rivers of Words<\/em><\/a>, Editor’s Choice), in The Economist on April 23rd: Mountains high enough and rivers wide enough<\/em><\/a>, and in the Danish newspaper Politiken<\/em> on August 24th:
\nFloder og bjerge holder styr p\u00e5 sprog<\/em><\/a>.<\/p>\n

2013<\/strong><\/h3>\n

99. What’s in a name? Comment on “Surname distribution in population genetics and in statistical physics”<\/a>
\nManrubia, S.
\nPhysics of Life Reviews<\/em> 10<\/strong>, 424-425<\/p>\n

98. Susanna Manrubia and Dami\u00e1n H. Zanette, Gens i genealogies. Sobre la nostra her\u00e8ncia cultural i gen\u00f2mica<\/a>
\n(Genes and genealogies. On our cultural and genomic inheritance.)<\/em> ISBN 9788490260852, 200 pp.
\nCol.lecci\u00f3 Sense Fronteres<\/em>, Edicions Bromera.<\/p>\n

97. Emergence and selection of biomodules: Steps in the assembly of a protocell<\/a>
\nManrubia, S. C. and Briones, C.
\nIn: Engineering of Chemical Complexity<\/a><\/em>, pp. 323-343. A. S. Mikhailov and G. Ertl, eds. World Scientific, Singapore.<\/p>\n

96. Shape matters: Effect of point mutations on RNA secondary structure<\/a>
\nManrubia, S. C. and Sanjuan, R.
\nAdvances in Complex Systems<\/em> 16<\/strong>, 1250052<\/p>\n

2012<\/strong><\/h3>\n

95. \u00c9s la vida un imperatiu c\u00f2smic? Reflexions sobre la recerca i les expectatives<\/a>
\nManrubia, S. C.
\nM\u00c8TODE<\/em> 75<\/strong>, 12-16<\/p>\n

94.\u00a0The impact of quasispecies dynamics on the use of therapeutics<\/a>
\nPerales, C., Iranzo, J., Manrubia, S. C. and Domingo, E.
\nTrends in Microbiology<\/em> 20<\/strong>, 595-603
\n<\/em><\/p>\n

93. Neutral networks and chemical function in RNA. Comment on “Evolutionary dynamics of RNA-like replicator systems: a bioinformatic approach to the origin of life”<\/a>
\nManrubia, S. C.
\nPhysics of Life Reviews<\/em> 9<\/strong>, 277-278<\/p>\n

92. Modelling viral evolution and adaptation: challenges and rewards<\/a>
\nManrubia, S. C.
\nCurrent Opinion in Virology<\/em> 2<\/strong>, 531-537<\/p>\n

91. Role of demographic dynamics and conflict in the population-area relationship for human languages<\/a>
\nManrubia, S. C., Axelsen, J. B. and Zanette, D. H.
\nPLoS ONE<\/em> 7<\/strong>, e40137
\nRead the post by Anxo S\u00e1nchez<\/a>, a popular science exposition of our results (in Spanish): Lenguas, evoluci\u00f3n, demograf\u00eda y conflictos<\/a><\/em><\/p>\n

90. Evolutionary dynamics of genome segmentation in multipartite viruses<\/a>
\nIranzo, J. and Manrubia, S. C.
\nProceedings of the Royal Society of London B<\/em> 279<\/strong>, 3812-3819<\/p>\n

2011<\/strong><\/h3>\n

89. Severe hindrance of viral infection propagation in spatially extended hosts<\/a>
\nCapit\u00e1n, J. A., Cuesta, J. A., Manrubia, S. C., and Aguirre, J.
\nPLoS ONE<\/em> 6<\/strong>, e23358<\/p>\n

88. Tempo and mode of inhibitor-mutagen antiviral therapies: A multidisciplinary approach<\/a>
\nIranzo, J., Perales, C., Domingo, E., and Manrubia, S. C.
\nProceedings of the National Academy of Sciences USA<\/em> 108<\/strong>, 16008-16013<\/p>\n

87. Topological structure of the space of phenotypes: the case of RNA neutral networks<\/a>
\nBuld\u00fa, J. M., Aguirre, J., Stich, M., and Manrubia, S. C.
\nPLoS ONE<\/em> 6<\/strong>, e26324<\/p>\n

86. Motif frequency and evolutionary search times in RNA populations<\/a>
\nStich, M. and Manrubia, S. C.
\nJournal of Theoretical Biology<\/em> 280<\/strong>, 117-126<\/p>\n

85. Influence of mutagenesis and viral load in sustained, low-level replication of an RNA virus<\/a>
\nPerales, C., Agudo, R., Manrubia, S. C., and Domingo, E.
\nJournal of Molecular Biology<\/em> 407<\/strong>, 60<\/p>\n

84. The struggle for space: Viral extinction through competition for cells<\/a>
\nCuesta, J. A., Aguirre, J., Capit\u00e1n, J.A., and Manrubia, S. C.
\nPhysical Review Letters<\/em> 106<\/strong>, 028104<\/p>\n

83. Particle stability, a non-replicative trait in the transition towards viral genome segmentation<\/a>
\nOjosnegros, S., Garc\u00eda-Arriaza, J., Escarm\u00eds, C., Manrubia, S. C., Perales, C., Arias, A., Mateu, M. G., and Domingo, E.
\nPLoS Genetics<\/em> 7<\/strong>, e1001344Multiplicative processes in social systems<\/p>\n

2010<\/strong><\/h3>\n

82. Phenotypic effect of mutations in evolving populations of RNA molecules<\/a>
\nStich, M., L\u00e1zaro, E., and Manrubia, S. C.
\nBMC Evolutionary Biology<\/em> 10<\/strong>, 46<\/p>\n

81. Pathways to Extinction — Beyond the Error Threshold<\/a>
\nManrubia S. C., Domingo, E., and L\u00e1zaro, E.
\nPhilosophical Transactions of the Royal Society<\/em> 365<\/strong>, 1943-1952<\/p>\n

80. A model for the modular evolution of RNA addressing open questions on the origin of life<\/a>
\nBriones, C., Stich, M., and Manrubia, S. C.
\nOrigins of Life and Evolution of Biospheres<\/em> 40<\/strong>, 429-432<\/p>\n

79. Variable mutation rates as an adaptive strategy in replicator populations<\/a>
\nStich, M., Manrubia, S. C., and L\u00e1zaro, E.
\nPLoS ONE<\/em> 5<\/strong>, e11186<\/p>\n

78. Populations of RNA molecules as computational model for evolution<\/a>
\nStich, M., Briones, C., L\u00e1zaro, E., and Manrubia, S. C.
\nIn: Evolutionary Biology — Concepts, molecular, and morphological evolution<\/em>. P. Pontarotti (Ed.), pp. 67-79, Springer, Heidelberg.<\/p>\n

77. Neutral networks of genotypes: Evolution behind the curtain<\/a>
\nManrubia, S. C. and Cuesta, J.
\nARBOR – Ciencia, pensamiento y cultura<\/em> 746<\/strong>, 1051-1064<\/p>\n

2009<\/strong><\/h3>\n

76. Stochastic extinction of viral infectivity through the action of defectors<\/a>
\nIranzo, J. and Manrubia, S. C.
\nEurophysics Letters<\/em> 85<\/strong>, 18001
\nHighlighted in SINC<\/a> (Service of Information and Scientic News) of FECYT, 22nd April 2009.<\/p>\n

75. The dawn of the RNA world: Towards functional complexity through ligation of random RNA oligomers<\/a>
\nBriones, C., Stich, M. and Manrubia, S. C.
\nRNA<\/em> 15<\/strong>, 743-749<\/p>\n

74. Topological properties of phylogenetic trees in evolutionary models<\/a>
\nStich, M. and Manrubia, S. C.
\nEuropean Physical Journal B<\/em> 70<\/strong>, 583-592<\/p>\n

73. A trade-off between fast growth and diversity generation limits the optimization of viral quasispecies<\/a>
\nAguirre, J., L\u00e1zaro, E., and Manrubia, S. C.
\nJournal of Theoretical Biology<\/em> 261<\/strong>, 148-155<\/p>\n

72. Biodiversidad, asexualidad y virus: tres esbozos sobre la complejidad de la evoluci\u00f3n<\/a>
\nManrubia, S. C.
\nApuntes de Ciencia y Tecnolog\u00eda<\/em> 32<\/strong>, 29-36<\/p>\n

71. Potential benefits of sequential inhibitor-mutagen lethal mutagenesis treatments of RNA virus infections<\/a>
\nPerales, C., Agudo, R., Tejero, H., Manrubia, S. C., and Domingo, E.
\nPLoS Pathogens<\/em> 5<\/strong>, e1000658<\/p>\n

70. Evolutionary dynamics on networks of selectively neutral genotypes: Effects of topology and sequence stability<\/a>
\nAguirre, J., Buld\u00fa, J. M., and Manrubia, S. C.
\nPhysical Review E<\/em> 80<\/strong>, 066112<\/p>\n

2008<\/strong><\/h3>\n

69. Fractal properties of isolines at varying altitude revealing different dominant geological processes on Earth<\/a>
\nBaldassarri, A., Montuori, M., Prieto-Ballesteros, O., and Manrubia, S. C.
\nJournal of Geophysical Research – Planets<\/em> 113<\/strong>, E09002<\/p>\n

68. Effects of spatial competition in the diversity of a quasispecies<\/a>
\nAguirre, J. and Manrubia, S. C.
\nPhysical Review Letters<\/em> 100<\/strong>, 038106<\/p>\n

67. On the structural repertoire of pools of short, random RNA sequences<\/a>
\nStich, M., Briones, C. and Manrubia, S. C.
\nJournal of Theoretical Biology<\/em> 252<\/strong>, 750-763<\/p>\n

2007<\/strong><\/h3>\n

66. Modular evolution and increase of functional complexity in replicating RNA molecules<\/a>
\nManrubia, S. C. and Briones, C.
\nRNA<\/em> 13<\/strong>, 97-107<\/p>\n

65. Out-of-equilibrium competitive dynamics of quasispecies<\/a>
\nAguirre, J. and Manrubia, S. C.
\nEurophysics Letters<\/em> 77<\/strong>, 38001<\/p>\n

64. Collective properties of quasispecies in molecular evolution<\/a>
\nStich, M., Briones, C., and Manrubia, S. C.
\nBMC Evolutionary Biology<\/em> 7<\/strong>, 110<\/p>\n

63. Multiplicative processes in social systems<\/a>
\nZanette, D. H. and Manrubia, S. C.
\nIn: Spatiotemporal Patterns, Networks and Synchronization in Biological, Ecological and Social systems.<\/em> World Scientic Lecture Notes in Complex Systems, Vol. 7. B. Blasius, J. Kurths, and L. Stone, eds. pp. 129-158.<\/p>\n

62. Astrobiolog\u00eda. En busca de los l\u00edmites de la vida<\/a>
\nManrubia, S. C.
\nin Encuentros con la ciencia: del macrocosmos al microcosmos<\/em>, chapter 3 (pp. 65-78). E. Viguera, A. Grande-P\u00e9rez, and Jos\u00e9 Lozano (eds.). Editorial Ogijares, 304 pp.<\/p>\n

61. En busca de los l\u00edmites de la vida. Claves desde la Tierra<\/a>
\nManrubia, S. C.
\nMonograf\u00edas de la Real Academia de Ciencias Exactas, F\u00edsicas, Qu\u00edmicas y Naturales de Zaragoza<\/em> 62<\/strong>, 119-133<\/p>\n

2006<\/strong><\/h3>\n

60. Population bottlenecks in quasispecies dynamics<\/a>
\nL\u00e1zaro, E., Escarm\u00eds, C., and Manrubia, S.C.
\nCurrent Topics in Microbiology and Immunology<\/em> 299<\/strong>, 141-170<\/p>\n

59. Long-range transport and universality classes in in vitro viral infection spread<\/a>
\nManrubia, S. C., Garc\u00eda-Arriaza, J., Domingo, E., and Escarm\u00eds, C.
\nEurophysics Letters<\/em> 74<\/strong>, 547-553<\/p>\n

58. Viral evolution<\/a>
\nManrubia, S. C. and L\u00e1zaro, E.
\nPhysics of Life Reviews<\/em> 3<\/strong>, 65-92<\/p>\n

57. Spiders: Water driven erosive structures in the southern hemisphere of Mars<\/a>
\nPrieto, O., Fern\u00e1ndez-Remolar, D., Selsis, F., Rodr\u00edguez-Manfredi, J. A., and Manrubia, S. C.
\nAstrobiology<\/em> 6<\/strong>(4), 651-667
\nThis contribution was featured in the cover of the corresponding Astrobiology issue<\/a>.<\/p>\n

56. Eukaryotic community distribution and its relationship to water physicochemical parameters in an extreme acidic environment, R\u00edo Tinto (Southwestern Spain))<\/a>
\nAguilera, A., Manrubia, S.C., G\u00f3mez, F., Rodr\u00edguez, N., and Amils, R.
\nApplied and Environmental Microbiology<\/em> 72<\/strong>(8), 5325-5330<\/p>\n

55. Evolution of fast mutating replicators — RNA viruses and the RNA world<\/a>
\nManrubia, S.C.
\nPhysica A<\/em> 371<\/strong>(1), 80-83<\/p>\n

2005<\/strong><\/h3>\n

54. Biodiversity in model ecosystems. II: Species assembly and ecosystem structure<\/a>
\nBastolla, U., L\u00e4ssig, M., Manrubia, S.C., and Valleriani, A.
\nJournal of Theoretical Biology<\/em> 235<\/strong>, 531-539<\/p>\n

53. Biodiversity in model ecosystems. I: Coexistence conditions for competing species<\/a>
\nBastolla, U., L\u00e4ssig, M., Manrubia, S.C., and Valleriani, A.
\nJournal of Theoretical Biology<\/em> 235<\/strong>, 521-530<\/p>\n

52. Foot-and-mouth disease virus evolution: exploring pathways towards virus extinction<\/a>
\nDomingo, E., Pariente, N., Airaksinen, A., Gonz\u00e1alez, C., Sierra, S., Herrera, M., Grande, A., Lowenstein, P., Manrubia, S.C., L\u00e1zaro, E., and Escarm\u00eds, C.
\nCurrent Topics in Microbiology and Immunology<\/em> 288<\/strong>, 149-173<\/p>\n

51. Phylogeny of organisms from functional data: The case of protein synthesis inhibition response<\/a>
\nBriones, C., Manrubia, S.C., L\u00e1zaro, E., Lazcano, A., and Amils, R.
\nMolecular Phylogenetics and Evolution<\/em> 34<\/strong>, 371-381<\/p>\n

50. Quasispecies dynamics and RNA virus extinction<\/a>
\nDomingo, E., Escarm\u00eds, C., L\u00e1zaro, E., and Manrubia, S. C.
\nVirus research<\/em> 107<\/strong>, 129-139<\/p>\n

49. Suppression of viral infectivity through lethal defection<\/a>
\nGrande-P\u00e9rez, A., L\u00e1zaro, E., Domingo, E., and Manrubia, S. C.
\nProceedings of the National Academy of Sciences<\/em> 102<\/strong>, 4448-4452
\nThe research reported was awarded a national prize (Diario Medico, Best Scientific Ideas 2005<\/a>).<\/p>\n

48. High mutation rates, bottlenecks, and robustness of RNA viral quasispecies<\/a>
\nManrubia, S.C., Escarm\u00eds, C., Domingo, E., and L\u00e1zaro, E.
\nGene<\/em>, section Evolutionary Genomics 347<\/strong>, 273-282<\/p>\n

2004<\/strong><\/h3>\n

47. S.C. Manrubia, A.S. Mikhailov, and D.H. Zanette, Emergence of Dynamical Order. Synchronization Phenomena in Complex Systems<\/em><\/a>. Lecture Notes in Complex Systems, Vol. 2, 360 pp., ISBN 981-238-803-6. World Scientic Publishing Co., Singapore.<\/p>\n

46. Evolutionary transition toward defective RNAs that are infectious by complementation<\/a>
\nGarc\u00eda-Arriaza, J., Manrubia, S.C., Toja, M., Domingo, E., and Escarm\u00eds, C.
\nJournal of Virology<\/em> 78<\/strong>, 11678-11685<\/p>\n

2003<\/strong><\/h3>\n

45. Supercritical branching processes and the role of fluctuations under exponential population growth<\/a>
\nManrubia, S.C., Arribas, M., and L\u00e1zaro, E.
\nJournal of Theoretical Biology<\/em> 225<\/strong>(4), 497-505<\/p>\n

44. Genealogy in the era of genomics<\/a>
\nManrubia, S.C., Derrida, B., and Zanette, D.
\nAmerican Scientist<\/em> 91<\/strong>, 158-165, March-April 2003
\nTranslation to French: La g\u00e9n\u00e9alogie \u00e0 l’\u00e8re de la g\u00e9nomique<\/a>. Pour la Science <\/em>46<\/strong>, 98-103 (2005)
\nTranslation to German: Im Dickicht der Stammb\u00e4ume<\/a>. Spektrum der Wissenschaft<\/em>, September 2007<\/p>\n

43. Fitness distribution in exponentially growing asexual populations<\/a>
\nManrubia, S.C., L\u00e1zaro, E., P\u00e9rez-Mercader, J., Escarm\u00eds, C., and Domingo, E.
\nPhysical Review Letters<\/em> 90<\/strong>, 188102<\/p>\n

42. Resistance of virus to extinction upon bottleneck passages: study of a decaying and fluctuating pattern of fitness loss<\/a>
\nL\u00e1zaro, E., Escarm\u00eds, C., P\u00e9rez-Mercader, J., Manrubia, S.C., and Domingo, E.
\nProceedings of the National Academy of Sciences<\/em> 100<\/strong>, 10830-10835<\/p>\n

41. Motif selection in a model of evolving replicators: The role of surfaces and limited transport in network topology<\/a>
\nManrubia, S.C. and Poyatos, J.
\nEurophysics Letters<\/em> 64<\/strong>(4), 557-563<\/p>\n

2002<\/strong><\/h3>\n

40. At the boundary between biological and cultural evolution: The origin of surname distributions<\/a>
\nManrubia, S.C. and Zanette, D.H.
\nJournal of Theoretical Biology<\/em> 216<\/strong>, 461-477
\nFeatured in New Scientist<\/em><\/a>, 23 March 2002.<\/p>\n

39. Modeling viral genome fitness evolution associated with serial bottleneck events: Evidence of stationary states of fitness<\/a>
\nL\u00e1zaro, E., Escarm\u00eds, C., Domingo, E., and Manrubia, S.C.
\nJournal of Virology<\/em> 76<\/strong>, 8675-8681<\/p>\n

38. Scaling of void sizes and fractality in the galaxy distribution<\/a>
\nGaite, J. and Manrubia, S.C.
\nMonthly Notices of the Royal Astronomical Society<\/em> 335<\/strong>, 977-983<\/p>\n

37. Dynamics and topology of species networks<\/a>
\nValleriani, A., L\u00e4ssig, M., Manrubia, S.C., and Bastolla, U.
\nIn: Biological Evolution and Statistical Physics<\/em>, M. L\u00e4ssig and A. Valleriani eds. Springer-Verlag.<\/p>\n

2001<\/strong><\/h3>\n

36. On the fractal nature of ecological and macroevolutionary dynamics<\/a>
\nSol\u00e9, R.V., Alonso, D., Bascompte, J., and Manrubia, S.C.
\nFractals<\/em> 9<\/strong>, 1-16<\/p>\n

35. Globally coupled logistic maps as dynamical glasses<\/a>
\nManrubia, S.C. and Mikhailov, A.S.
\nEurophysics Letters <\/em>53<\/strong>, 451-457<\/p>\n

34. Small-world behaviour in a system of mobile elements<\/a>
\nManrubia, S.C., Delgado, and J., Luque, B.
\nEurophysics Letters<\/em> 53<\/strong>, 693-699<\/p>\n

33. Shape of ecological networks<\/a>
\nL\u00e4ssig, M., Bastolla, U., Manrubia, S.C., and Valleriani, A.
\nPhysical Review Letters<\/em> 86<\/strong>, 4418-4421<\/p>\n

32. Vertical transmission of culture and the distribution of family names<\/a>
\nZanette, D.H. and Manrubia, S.C.
\nPhysica A<\/em> 295<\/strong>, 1-8<\/p>\n

31. Diversity patterns from ecological models at dynamical equilibrium<\/a>
\nBastolla, U., L\u00e4ssig, M., Manrubia, S.C., and Valleriani, A.
\nJournal of Theoretical Biology<\/em> 212<\/strong>, 11-34<\/p>\n

30. Replica symmetry breaking in dynamical glasses<\/a>
\nManrubia, S.C., Bastolla, U., and Mikhailov, A.S.
\nEuropean Physical Journal B<\/em> 23<\/strong>, 497-506<\/p>\n

XXth Century<\/strong><\/h3>\n

29. Synchronization and clustering in coupled saw-tooth maps
\nManrubia, S.C. and Mikhailov, A.S.
\nInternational Journal of Bifurcations and Chaos<\/em> 10<\/strong>, 2465-2478 (2000)<\/p>\n

28. On the genealogy of a population of biparental individuals<\/a>
\nDerrida, B., Manrubia, S.C., Zanette, D.H.
\nJournal of theoretical Biology<\/em> 203<\/strong>, 303-315 (2000)<\/p>\n

27. Very long transients in globally coupled maps<\/a>
\nManrubia, S.C. and Mikhailov, A.S.
\nEurophysics Letters<\/em> 50<\/strong>, 580-586 (2000)<\/p>\n

26. Distribution of repetitions of ancestors in genealogical trees<\/a>
\nDerrida, B., Manrubia, S.C., Zanette, D.H.
\nPhysica A<\/em> 281<\/strong>, 1-16 (2000)<\/p>\n

25. Self-organized criticality in ecology and evolution (reply)<\/a>
\nSol\u00e9, R.V., Manrubia, S.C., Benton, M.J., Kauffman, S. and Bak, P.
\nTrends in Ecology and Evolution <\/em>14<\/strong>, 321-322 (1999)<\/p>\n

24. Statistical properties of genealogical trees<\/a>
\nDerrida, B., Manrubia, S.C. and Zanette, D.H.
\nPhysical Review Letters<\/em> 82<\/strong>, 1987-1990 (1999)
\nFeatured in Physics World<\/em><\/a>, April 1999 (Family ties<\/em>), and in the Physics Bulletin of Physics News<\/em><\/a> (American Institute of Physics) 428<\/strong>, May 14, 1999 (King Edward III<\/em>).<\/p>\n

23. Transient dynamics and scaling phenomena in urban growth<\/a>
\nManrubia, S.C., Zanette, D.H. and Sol\u00e9, R.V.
\nFractals<\/em> 7<\/strong>(1), 1-8 (1999)<\/p>\n

22. Stochastic multiplicative processes with reset events<\/a>
\nManrubia, S.C. and Zanette, D.H.
\nPhysical Review E<\/em> 59<\/strong>, 4945-4948 (1999)<\/p>\n

21. Mutual synchronization and clustering in randomly coupled chaotic dynamical networks<\/a>
\nManrubia, S.C. and Mikhailov, A.S.
\nPhysical Review E<\/em> 60<\/strong>, 1579-1589 (1999)<\/p>\n

20. Criticality and scaling in evolutionary ecology<\/a>
\nSol\u00e9, R.V., Manrubia, S.C., Benton, M.J., Kauffman, S. and Bak, P.
\nTrends in Ecology and Evolution <\/em>14<\/strong>, 156-160 (1999)<\/p>\n

19. Intermittency model for urban development<\/a>
\nManrubia, S.C. and Zanette, D.H.
\nPhysical Review E<\/em> 58<\/strong>, 295-302 (1998)<\/p>\n

18. Reply to: Comment on “Role of intermittency in urban development: A model of large-scale city formation”<\/a>
\nZanette, D.H. and Manrubia, S.C.
\nPhysical Review Letters <\/em>80<\/strong>, 4831 (1998)<\/p>\n

17. A simple model of large-scale organization in evolution<\/a>
\nManrubia, S.C. and Paczuski, M.
\nInternational Journal of Modern Physics C<\/em> 9<\/strong>, 1025-1032 (1998)<\/p>\n

16. Long-range correlations in the fossil record and the fractal nature of macroevolution
\nSol\u00e9, R.V., Manrubia, S.C., P\u00e9rez-Mercader, J., Benton, M.J., and Bak, P.
\nAdvances in Complex Systems <\/em>1<\/strong>(2), 255-266 (1998)<\/p>\n

15. On forest spatial dynamics with gap formation<\/a>
\nManrubia, S.C. and Sol\u00e9, R.V.
\nJournal of Theoretical Biology<\/em> 187<\/strong>, 159-164 (1997)<\/p>\n

14. Self-similarity of extinction statistics in the fossil record<\/a>
\nSol\u00e9, R.V., Manrubia, S.C., Benton, M.J. and Bak, P.
\nNature <\/em>388<\/strong>, 764-767 (21 August 1997).
\nFeatured in New Scientist<\/em><\/a>, 8 November 1997 (One law to rule them all<\/em>), and in The New York Times<\/em><\/a>, 2 September 1997 (Many small events may add up to one mass extinction<\/em>).<\/p>\n

13. Aftershock series of event February 18, 1996: An interpretation in terms of self-organized criticality<\/a>
\nCorreig, A., Urquizu, M., Manrubia, S.C. and Vila, J.
\nJournal of Geophysical Research <\/em>102<\/strong>, 407-420 (1997)<\/p>\n

12. Role of intermittency in urban development: A model of large-scale city formation<\/a>
\nZanette, D.H. and Manrubia, S.C.
\nPhysical Review Letters <\/em>79<\/strong>, 523-526 (1997)
\nFeatured in Physics World<\/em><\/a>, October 1997 (Power laws for cities<\/em>).<\/p>\n

11. Criticality and Unpredictability in Macroevolution<\/a>
\nSol\u00e9, R.V. and Manrubia, S.C.
\nPhysical Review E<\/em> 55<\/strong>, 4500-4507 (1997)<\/p>\n

10. Self-organized criticality in rainforest dynamics<\/a>
\nManrubia, S.C. and Sol\u00e9, R.V.
\nChaos, Solitons and Fractals <\/em>7<\/strong>(4), 523-541 (1996)<\/p>\n

9. Phase transitions and complex systems<\/a>
\nSol\u00e9, R.V., Manrubia, S.C., Bascompte, J., Delgado, J. and Luque, B.
\nComplexity <\/em>1<\/strong>, 13-26 (1996)<\/p>\n

8. Extinction and self-organized criticality in a model of large-scale evolution<\/a>
\nSol\u00e9, R.V. and Manrubia, S.C.
\nPhysical Review E<\/em> 54<\/strong>, R42-R45 (1996)<\/p>\n

7. Extinctions: Bad genes or weak chaos?<\/a>
\nSol\u00e9, R.V., Bascompte, J. and Manrubia, S.C.
\nProceedings of the Royal Society of London B <\/em>263<\/strong>, 1407-1413 (1996)<\/p>\n

6. Complejidad en la Frontera del Caos<\/a>
\nSol\u00e9, R.V., Bascompte, J., Delgado, J., Luque, B. and Manrubia, S.C.
\nInvestigacion y Ciencia<\/em>, May 1996, 14-21 (Spanish issue of Scientic American<\/em>).<\/p>\n

5. Self-similarity in rainforests: Evidence for a critical state<\/a>
\nSol\u00e9, R.V. and Manrubia, S.C.
\nPhysical Review E<\/em> 51<\/strong>, 6250-6253 (1995)<\/p>\n

4. Are rainforests self-organized in a critical state?<\/a>
\nSol\u00e9, R.V. and Manrubia, S.C.
\nJournal of Theoretical Biology<\/em> 173<\/strong>, 31-40 (1995)<\/p>\n

3. R.V. Sol\u00e9 and S.C. Manrubia, Orden y Caos en Sistemas Complejos<\/em><\/a> (Order and Chaos in Complex Systems.<\/em>) Col.leccio Politext, Edicions UPC, Barcelona, 1996 (594 p.).<\/p>\n

2. Sol\u00e9, R.V., Manrubia, S.C. and Luque, B. (1994) Multifractals in rainforest ecosystems: Modelling and simulation. In: Fractals in the Natural and Applied Sciences<\/em>, North-Holland, Amsterdam, 397-407.<\/p>\n

1. Sol\u00e9, R.V., Manrubia, S.C. and Luque, B. (1993) Multifractality and complexity in rainforest dynamics. Proc. 1st Copenhagen Symposium on Computer Simulation in Biology, Ecology and Medecine<\/em>, 117-121.<\/p>\n","protected":false},"excerpt":{"rendered":"

2025 150. Hierarchical genotype networks and incipient ecological speciation in Q\u03b2 phage quasispecies Seoane, L.F., Secaira-Morocho, H., L\u00e1zaro, E., Manrubia, S. arXiv preprint arXiv:2411.07110 149. Assay: Paradoxes dels viatges en el temps (Paradoxes of time travel) Manrubia, S. to appear … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":43,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"full-width-page.php","meta":{"footnotes":""},"class_list":["post-24","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/auditore.cab.inta-csic.es\/manrubia\/wp-json\/wp\/v2\/pages\/24","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/auditore.cab.inta-csic.es\/manrubia\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/auditore.cab.inta-csic.es\/manrubia\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/auditore.cab.inta-csic.es\/manrubia\/wp-json\/wp\/v2\/users\/43"}],"replies":[{"embeddable":true,"href":"https:\/\/auditore.cab.inta-csic.es\/manrubia\/wp-json\/wp\/v2\/comments?post=24"}],"version-history":[{"count":309,"href":"https:\/\/auditore.cab.inta-csic.es\/manrubia\/wp-json\/wp\/v2\/pages\/24\/revisions"}],"predecessor-version":[{"id":1425,"href":"https:\/\/auditore.cab.inta-csic.es\/manrubia\/wp-json\/wp\/v2\/pages\/24\/revisions\/1425"}],"wp:attachment":[{"href":"https:\/\/auditore.cab.inta-csic.es\/manrubia\/wp-json\/wp\/v2\/media?parent=24"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}